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South San Francisco is a city in San Mateo County, California, United States, located on the San Francisco Peninsula in the San Francisco Bay Area. The population was 63,632 at the 2010 census.
The 2010 United States Census reported that South San Francisco had a population of 63,632. The population density was 6,961.2 people per square mile (2,687.8/km²).
The Census reported that 63,053 people (99.1% of the population) lived in households, 528 (0.8%) lived in non-institutionalized group quarters, and 51 (0.1%) were institutionalized.
There were 20,938 households, out of which 7,588 (36.2%) had children under the age of 18 living in them, 11,165 (53.3%) were married couples, 2,897 (13.8%) had a female householder with no husband present, 1,268 (6.1%) had a male householder with no wife present. There were 1,083 (5.2%) unmarried couples, and 187 (0.9%) same-sex couples. 4,299 households (20.5%) were made up of individuals and 1,857 (8.9%) had someone living alone who was 65 years of age or older. The average household size was 3.01. There were 15,330 families (73.2% of all households); the average family size was 3.45.